منابع مشابه
Toxicity of atorvastatin on isolated brain mitochondria
Background: Although the bio kinetics, metabolism and chemical toxicity of Atorvastatin are well known, until recently little attention was paid to the potential neurotoxic effect of Atorvastatin (Atv). Regarding the concrete evidences indicating Atv may reduce Coenzyme Q10 (CoQ10) levels through blockage of metalonate cycle, the present work aims to determine if Atorvastatin may provide toxic...
متن کاملMetabolism of rat brain mitochondria. Studies on the potassium ion-stimulated oxidation of pyruvate.
1. Rat brain-cortex mitochondria were incubated in media containing 1, 5 or 100mm-K(+) in the presence of ADP, uncoupler (FCCP, carbonyl cyanide p-trifluoro-methoxyphenylhydrazone) or valinomycin while metabolizing pyruvate and malate, or acetylcarnitine and malate or glutamate and malate as substrates. Both the uptake of oxygen and disappearance of substrate were measured under these condition...
متن کاملThe regulation of glutamate metabolism by tricarboxylic acid-cycle activity in rat brain mitochondria.
1. The interrelationship of metabolism of pyruvate or 3-hydroxybutyrate and glutamate transamination in rat brain mitochondria was studied. 2. If brain mitochondria are incubated in the presence of equimolar concentrations of pyruvate and glutamate and the K(+) concentration is increased from 1 to 20mm, the rate of pyruvate utilization is increased 3-fold, but the rate of production of aspartat...
متن کاملThe metabolism of glyoxylate by human- and rat-liver mitochondria.
Manners, D. J. (1959). Roy. Indt. Chem. Monogr. no. 2: Structural Analysis of Poly8accharides. Neely, W. B. (1960). Advanc. Carbohyd. Chem. 15, 341. Schwimmer, S. & Bevenue, A. (1956). Science, 123, 543. Scott, T. A., Hellman, N. N. & Senti, F. R. (1957). J. Amer. chem. Soc. 79, 1178. Shaffer, P. A. & Hartmann, A. F. (1921). J. biol. Chem. 124, 425. Trevelyan, W. E., Procter, D. P. & Harrison, ...
متن کاملA Search for Mitochondrial Damage in Alzheimer’s Disease Using Isolated Rat Brain Mitochondria
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62854-6